BCMB 405 — Cell Signalling
Biochemistry, Cell and Molecular Biology · University of Ghana
Types of cellular regulation: endocrine, paracrine, autocrine, direct cell-to-cell communication Primary signalling molecules: growth factors, hormones, neurotransmitters Structure and properties of receptors: Cell surface and intracellular receptors, G-protein coupled receptors, receptor tyrosine kinases. Conserved domains, ligand recognition, binding characteristics, receptor dimerization and phosphorylation, docking sites and substrate interactions. Guanine nucleotide binding-protein switches: Heterotrimeric and monomeric, G-protein regulators - GTPase activating proteins and guanine nucleotide exchange factors e.g. Son of sevenless, neurofibromin. Second messenger generation: cyclic AMP, cyclic GMP, inositol trisphosphate, diacylglycerol, Ca2+ Examples of major cascades: Ras-mitogen activated protein kinase pathway, phosphatidylinositol-3-kinase and Akt pathway, Janus kinase and Signal transducer and Activator of Transcription pathway (JAK-STAT), Nitric oxide-guanylyl cyclase signaling. Effectors, transcription factors, amplification, signal diversity, cross-talk and signal termination.
- Credits
- 2
- Level
- Level 400
- Semester
- Semester One
Other courses on this programme
- BCMB 400 — Project
- BCMB 401 — Protein Chemistry I
- BCMB 402 — Protein Chemistry II
- BCMB 403 — Molecular Biotechnology & Applications
- BCMB 404 — Immunology and Immunochemistry
- BCMB 406 — Molecular Genetics
- BCMB 407 — Cell & Molecular Biology Practical Ii
- BCMB 408 — Entrepreneurship For Innovations In Biosciences
- BCMB 409 — Biochemistry of Parasites
- BCMB 410 — Seminars and Scientific Writing
- BCMB 411 — Clinical Biochemistry
- BCMB 414 — Plant Biochemistry
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Start freeCourse details from University of Ghana Volume 3 Handbook for the Bachelor's Degree: Course Descriptions for Programmes in the Sciences (2017).