BCMB 415 — Xenobiotic Metabolism
Biochemistry, Cell and Molecular Biology · University of Ghana
Pathways of xenobiotic metabolism; Phase I and II reactions. Enzymology and molecular mechanisms of xenobiotic metabolism; cytochrome P-450-dependent mixed-function oxidation reactions, microsomal flavin-containing monooxygenases, prostaglandin synthetase, reduction enzymes, epoxide hydrolase and conjugating enzymes. Factors affecting xenobiotic metabolism; internal and external. Pharmacological and toxicological aspects of xenobiotic metabolism - Pharmacological; activation and deactivation, changes in pharmacological response, drug uptake and distribution, enterohepatic circulation. Toxicological; metabolic activation (increased toxicity) - carcinogenesis, mutagenesis, teratogenesis, pulmonary, hepatic and renal toxicities. Deactivation (decreased toxicity). Balance between toxification and detoxifying pathways.
- Credits
- 2
- Level
- Level 400
- Semester
- Semester One
Other courses on this programme
- BCMB 400 — Project
- BCMB 401 — Protein Chemistry I
- BCMB 402 — Protein Chemistry II
- BCMB 403 — Molecular Biotechnology & Applications
- BCMB 404 — Immunology and Immunochemistry
- BCMB 405 — Cell Signalling
- BCMB 406 — Molecular Genetics
- BCMB 407 — Cell & Molecular Biology Practical Ii
- BCMB 408 — Entrepreneurship For Innovations In Biosciences
- BCMB 409 — Biochemistry of Parasites
- BCMB 410 — Seminars and Scientific Writing
- BCMB 411 — Clinical Biochemistry
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Start freeCourse details from University of Ghana Volume 3 Handbook for the Bachelor's Degree: Course Descriptions for Programmes in the Sciences (2017).