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BCMB 304 — Molecular Biology II

Biochemistry, Cell and Molecular Biology · University of Ghana

The genetic code: Deciphering the code. Universality and degeneracy of the genetic code. Wobble hypothesis, colinearity of gene polypeptide. Translation: Ribosome structure. Activation of Amino acids. Initiation, elongation and termination. Eukaryotic and prokaryotic. Post-translational modifications; Polysomes, inhibitors of protein synthesis. Control of gene expression: Inducible and repressible operons, (lac and trp operons). Mutation: molecular basis of mutation. Point mutation – transitions, transversions, frameshift mutations. Site-directed mutagenesis, Radiation induced mutation. Chemically induced mutation. DNA repair mechanisms. Recombinant DNA and genetic engineering: Restriction endonucleases, Methods for recombinant DNA production, transformation, amplification, screening for cloned DNA.

Credits
2
Level
Level 300
Semester
Semester Two

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Course details from University of Ghana Volume 3 Handbook for the Bachelor's Degree: Course Descriptions for Programmes in the Sciences (2017).